Strategy for the Digitalization of the Local Television Program Archives in Saxony

The German Free State of Saxony has a high density of independent local and regional television broadcasters. From the antenna communities at the time of the GDR, private TV broadcasters developed after the reunification. In the period of the social transformations in the 1990s, these local TV stations documented the profound changes of the everyday life of the individual, of the local communities and the historical transformations in society and economy during the early years after the German reunion. These recordings are a substantial part of the cultural heritage of Saxony and of the highest interest for social, cultural and media research. Due to how the original material was produced on consumer videotapes, today the recordings are threatened by decay. In the next few years the recordings will be lost, if not acted quickly. Some state and private institutions are currently developing concepts for the preservation of the audiovisual heritage in Saxony In this paper, we discuss how these media objects should be scientifically investigated, in the sense of media and sociocultural dimensions, questions and categories. Based on our experiences and investigations, we present a technical concept which shows how to digitalize, index, describe and categorize copious amounts of videotapes for the preservation, archiving and public access of this important part of the cultural heritage of Germany

Neural Networks for Safety-Critical Applications - Challenges, Experiments and Perspectives

We propose a methodology for designing dependable Artificial Neural Networks (ANN) by extending the concepts of understandability, correctness, and validity that are crucial ingredients in existing certification standards. We apply the concept in a concrete case study in designing a high-way ANN-based motion predictor to guarantee safety properties such as impossibility for the ego vehicle to suggest moving to the right lane if there exists another vehicle on its right.Comment: Summary for activities conducted in the fortiss Eigenforschungsprojekt "TdpSW - Towards dependable and predictable SW for ML-based autonomous systems". All ANN-based motion predictors being formally analyzed are available in the source fil

Combining goal inference and natural-language dialogue for human-robot joint action

We demonstrate how combining the reasoning components from two existing systems designed for human-robot joint action produces an integrated system with greater capabilities than either of the individual systems. One of the systems supports primarily non-verbal interaction and uses dynamic neural fields to infer the user’s goals and to suggest appropriate system responses; the other emphasises natural-language interaction and uses a dialogue manager to process user input and select appropriate system responses. Combining these two methods of reasoning results in a robot that is able to coordinate its actions with those of the user while employing a wide range of verbal and non-verbal communicative actions.(undefined

KVP: A knowledge of volumes approach to robot task planning

Abstract — Robot task planning is an inherently challenging problem, as it covers both continuous-space geometric reasoning about robot motion and perception, as well as purely symbolic knowledge about actions and objects. This paper presents a novel “knowledge of volumes ” framework for solving generic robot tasks in partially known environments. In particular, this approach (abbreviated, KVP) combines the power of symbolic, knowledge-level AI planning with the efficient computation of volumes, which serve as an intermediate representation for both robot action and perception. While we demonstrate the effectiveness of our framework in a bimanual robot bartender scenario, our approach is also more generally applicable to tasks in automation and mobile manipulation, involving arbitrary numbers of manipulators. I

Free Fatty Acids in Bone Pathophysiology of Rheumatic Diseases

Obesity—in which free fatty acid (FFA) levels are chronically elevated—is a known risk factor for different rheumatic diseases, and obese patients are more likely to develop osteoarthritis (OA) also in non-weight-bearing joints. These findings suggest that FFA may also play a role in inflammation-related joint damage and bone loss in rheumatoid arthritis (RA) and OA. Therefore, the objective of this study was to analyze if and how FFA influence cells of bone metabolism in rheumatic diseases. When stimulated with FFA, osteoblasts from RA and OA patients secreted higher amounts of the proinflammatory cytokine interleukin (IL)-6 and the chemokines IL-8, growth-related oncogene α, and monocyte chemotactic protein 1. Receptor activator of nuclear factor kappa B ligand (RANKL), osteoprotegerin, and osteoblast differentiation markers were not influenced by FFA. Mineralization activity of osteoblasts correlated inversely with the level of FFA-induced IL-6 secretion. Expression of the Wnt signaling molecules, axin-2 and β-catenin, was not changed by palmitic acid (PA) or linoleic acid (LA), suggesting no involvement of the Wnt signaling pathway in FFA signaling for osteoblasts. On the other hand, Toll-like receptor 4 blockade significantly reduced PA-induced IL-8 secretion by osteoblasts, while blocking Toll-like receptor 2 had no effect. In osteoclasts, IL-8 secretion was enhanced by PA and LA particularly at the earliest time point of differentiation. Differences were observed between the responses of RA and OA osteoclasts. FFA might therefore represent a new molecular factor by which adipose tissue contributes to subchondral bone damage in RA and OA. In this context, their mechanisms of action appear to be dependent on inflammation and innate immune system rather than Wnt-RANKL pathways

Geographic variation in fitness-related traits of the bladderwrack Fucus vesiculosus along the Baltic Sea-North Sea salinity gradient

In the course of the ongoing global intensification and diversification of human pressures, the study of variation patterns of biological traits along environmental gradients can provide relevant information on the performance of species under shifting conditions. The pronounced salinity gradient, co-occurrence of multiple stressors, and accelerated rates of change make the Baltic Sea and its transition to North Sea a suitable region for this type of study. Focusing on the bladderwrack Fucus vesiculosus, one of the main foundation species on hard-bottoms of the Baltic Sea, we analyzed the phenotypic variation among populations occurring along 2,000 km of coasts subjected to salinities from 4 to >30 and a variety of other stressors. Morphological and biochemical traits, including palatability for grazers, were recorded at 20 stations along the Baltic Sea and four stations in the North Sea. We evaluated in a common modeling framework the relative contribution of multiple environmental drivers to the observed trait patterns. Salinity was the main and, in some cases, the only environmental driver of the geographic trait variation in F. vesiculosus. The decrease in salinity from North Sea to Baltic Sea stations was accompanied by a decline in thallus size, photosynthetic pigments, and energy storage compounds, and affected the interaction of the alga with herbivores and epibiota. For some traits, drivers that vary locally such as wave exposure, light availability or nutrient enrichment were also important. The strong genetic population structure in this macroalgae might play a role in the generation and maintenance of phenotypic patterns across geographic scales. In light of our results, the desalination process projected for the Baltic Sea could have detrimental impacts on F. vesiculosus in areas close to its tolerance limit, affecting ecosystem functions such as habitat formation, primary production, and food supply.Peer reviewe

In vitro measurement of temperature changes during implantation of cemented glenoid components

Background and purpose It is unclear whether the increase in temperature during cement curing may cause osteonecrosis, leading to loosening of the glenoid component in shoulder arthroplasty. We therefore analyzed the temperature during implantation of cemented glenoid implants

Platelet-rich plasma and tendons healing: rat model

peer reviewe